Category N: Not Symptomatic | Category C: Severely Symptomatic |
Children who have no signs or symptoms considered to
be the result of HIV infection or who have only one of
the conditions listed in Category A. | Children who have any condition listed in the 1987 Surveillance
Case definition for AIDS, with the exceptions of LIP (which is a
Category B condition): |
Serious bacterial infections,
multiple or recurrent (ie, any combination of at least two culture-confirmed
infections within a 2-year period), of the following types: septicemia, pneumonia,
meningitis, bone or joint infection, or abscess of an internal organ
or body cavity (excluding otitis media, superficial skin or mucosal
abscesses, and indwelling catheter–related infections) |
Category A: Mildly Symptomatic |
Children with two or more of the following
conditions but none of the conditions listed in Categories B and
C: |
Lymphadenopathy (⩾ 0.5 cm at
more than two sites; bilateral = one site) | Candidiasis, esophageal or pulmonary (bronchi, trachea, lungs) |
Coccidioidomycosis, disseminated (at site
other than or in addition to lungs or cervical or hilar lymph nodes) |
Hepatomegaly |
Splenomegaly | Cryptococcosis, extrapulmonary |
Dermatitis | Cryptosporidiosis or isosporiasis with diarrhea
persisting for less than 1 month |
Parotitis | Cytomegalovirus disease with
onset of symptoms at age older than 1 month (at a site other than
liver, spleen, or lymph nodes) |
Recurrent or persistent upper
respiratory infection, sinusitis, or otitis media |
Encephalopathy (at least one
of the following progressive findings present for at least 2 months
in the absence of a concurrent illness other than HIV infection
that could explain the findings): (a) failure to attain or loss
of developmental milestones or loss of intellectual ability, verified
by standard developmental scale or neuropsychological tests; (b)
impaired brain growth or acquired microcephaly demonstrated by head circumference
measurements or brain atrophy demonstrated by CT or MRI (serial imaging
is required for children younger than 2 years); (c) acquired symmetric
motor deficit manifested by two or more of the following: paresis,
pathologic reflexes, ataxia, or gait disturbance |
Category B: Moderately Symptomatic |
Children who have symptomatic conditions other than those
listed for Category A or C that are attributed to HIV infection.
Examples of conditions in Category B include, but are not limited
to: |
Anemia (< 8 g/dL),
neutropenia (< 1000 cells/mm3) or thrombocytopenia
(< 100,000 cells/mm3) persisting for 30 days
or longer | HSV infection causing a mucocutaneous ulcer that persist
for longer than 1 month; or bronchitis, pneumonitis, or esophagitis
for any duration affecting a child younger than 1 month |
Histoplasmosis, disseminated
(at a site other than or in addition to lungs or cervical or hilar
lymph nodes) |
Bacterial meningitis, pneumonia, or sepsis (single episode) |
Candidiasis, oropharyngeal (ie, thrush) persisting
for longer than 2 months in children younger than 6 months | Kaposi sarcoma |
Lymphoma, primary, in brain |
Cardiomyopathy | Lymphoma, small, noncleaved cell (Burkitt),
or immunoblastic or large cell lymphoma of B cell or unknown immunologic
phenotype |
Cytomegalovirus infection with
onset prior to 1 month of age |
Mycobacterium tuberculosis, disseminated or
extrapulmonary |
Diarrhea, recurrent or chronic | Mycobacterium, other species
or unidentified species, disseminated (at a site other than or in
addition to lungs, skin, or cervical or hilar lymph nodes) |
Hepatitis |
Herpes simplex virus (HSV) stomatitis, recurrent
(ie, more than two episodes within 1 year) | Mycobacterium avium complex
or Mycobacterium kansasii, disseminated (at site
other than or in addition to lungs, skin, or cervical or hilar lymph nodes) |
HSV bronchitis, pneumonitis,
or esophagitis with onset prior to 1 month of age | Pneumocystis jiroveci pneumonia |
Progressive multifocal leukoencephalopathy |
Herpes zoster (ie, shingles)
involving at least two distinct episodes or more than one dermatome | Salmonella (nontyphoid) septicemia, recurrent |
Toxoplasmosis of the brain with onset at older
than 1 month |
Leiomyosarcoma | Wasting syndrome in the absence
of a concurrent illness other than HIV infection that could explain
(a) persistent weight loss > 10% of baseline; OR (b) downward
crossing of at least the following percentile lines on the weight-for-age
chart (eg, 95th , 75th, 50th, 25th, 5th) in a child 1 year of age
and older; OR c) less than fifth percentile on weight-for-height
chart on two consecutive measurements, at least 30 days apart, PLUS (1)
chronic diarrhea (ie, at least two loose stools per day for more
than 30 days), OR (2) documented fever (for at least 30 days, intermittent
or constant) |
Lymphoid interstitial pneumonia (LIP) or pulmonary lymphoid
hyperplasia complex |
Nephropathy |
Nocardiosis |
Fever lasting longer than 1 month |
Toxoplasmosis with onset prior to 1 month of
age |
Varicella, disseminated (ie, complicated chickenpox) | |