History, physical examination, and skin biopsy can help differentiate
leiomyomas from angiolipomas, dermatofibromas, schwannomas, neurofibromas,
glomus tumors, osteoma cutis, eccrine spiradenomas, neuromas, and
neurilemmomas. Rarely, there can be leiomyosarcomas, which are typically
larger than their benign counterparts.