Most patients are most upset by the clinical appearance of the
lesions rather than the symptoms. Because localized trauma can precipitate
NL, elastic support stockings and leg rest may be helpful. Lesions
can be improved with topical or intralesional steroids. Antiplatelet
aggregation therapy (aspirin, dipyridamole, pentoxifylline, stanozolol,
inositol nicotinate, nicofuranose), TNF agents (etanercept, infliximab),
thalidomide, topical bovine collagen, topical GM–CSF, cyclosporine,
PUVA or UVA, mycophenolate mofetil, ticlopidine, nicotinamide, clofazimine,
local heparin injections, surgical grafting, and laser therapy all
have cases of reported success. Screening for DM is warranted if
systemic symptoms are present.