Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ Ephelis ++ Figure 26-1 Ephelis This is the learned word for a freckle. The plural is ephelides (pronounced ĕf-ĕl-ĩ-dēz). These brown macules are exceedingly common on the face in some children. They appear after exposure to sunlight and are more common in children with very fair skin or red hair. They tend to disappear in adult life. Histologically, these lesions show increased amounts of epidermal melanin but no abundance of melanocytes. Graphic Jump LocationView Full Size||Download Slide (.ppt) +++ Lentigo ++ Figure 26-2 Lentigo This tan-to-brown to almost brown-black macular lesion may be found on any area of the body surface, which includes mucous membranes. There is no relation to ultraviolet light exposure. The illustration here is of lentigines on the lip. Lentigines may be present at birth and tend to increase in number during childhood and adult life. Histologically, there is a proliferation of melanocytes and elongation of the rete ridges. Lesions of this sort show no tendency to resolve spontaneously. Graphic Jump LocationView Full Size||Download Slide (.ppt) +++ Peutz-Jeghers Syndrome ++ Figure 26-3 Peutz-Jeghers syndrome This autosomal dominant syndrome is notable for highly characteristic lentigines seen on the vermilion of the lips and adjacent skin, on the buccal mucosa, and on the palmar aspect of the fingertips. Figures 26-3 and 26-4 are good representations of the lentigines in a typical case. Graphic Jump LocationView Full Size||Download Slide (.ppt) ++ Figure 26-4 Patients with this syndrome may also have gastrointestinal polyps throughout the GI tract but most frequently in the jejunum. These benign hamartomas have very little malignant potential but may be the cause of obstruction, diarrhea, bleeding, or intussusception. Unlike common lentigines, the cutaneous lesions in these patients tend to fade during adult life. Mucous membrane lesions persist. Graphic Jump LocationView Full Size||Download Slide (.ppt) +++ Multiple Lentigines Syndrome ++ Figure 26-5 Multiple lentigines syndrome This autosomal dominant syndrome features numerous small lentigines, which are present at or soon after birth and cover the entire cutaneous surface. Previously known as the mnemonic LEOPARD syndrome, the common findings are summed up as follows in which l stands for lentigines, e for electrocardiographic conduction defects, o for ocular hypertelorism, p for pulmonary stenosis, a for abnormalities of genitalia, r for retardation of growth, and d for deafness. Mutations in the PTPN11, RAF1, or BRAF genes cause multiple lentigines syndrome. Graphic Jump LocationView Full Size||Download Slide (.ppt) +++ Junctional Nevus ++ Figure 26-6 Junctional nevus The macule of hyperpigmentation pictured in Fig. 26-6 is the most common form of nevocytic nevus in childhood. The so-called junctional nevus is a benign lesion that is composed of melanocytic nevus cells along the dermoepidermal junction. Lesions of this sort may arise in crops after the first ... Your Access profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth You already have access! Please proceed to your institution's subscription. Create a free a profile for additional features.