TY - CHAP M1 - Book, Section TI - Allergy and Asthma A1 - Fung, Irene A1 - Solrun Melkorka Maggadottir, A1 - Brown-Whitehorn, Terri A2 - Shah, Samir S. A2 - Zaoutis, Lisa B. A2 - Catallozzi, Marina A2 - Frank, Gary PY - 2016 T2 - The Philadelphia Guide: Inpatient Pediatrics, 2e AB - Anaphylaxis is an acute, potentially life-threatening systemic allergic reaction. It is most commonly triggered by interaction of an allergen with specific IgE antibody bound to mast cells and basophils leading to cell activation and mediator release. Non-IgE-mediated direct mast cell degranulation results in mediator release. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1122459018 ER -