TY - CHAP M1 - Book, Section TI - Errors of Metabolism in the Neonatal Period A1 - Wolf, Nicole I. A1 - Surtees, Robert A2 - Duchowny, Michael A2 - Cross, J. Helen A2 - Arzimanoglou, Alexis PY - 2017 T2 - Pediatric Epilepsy AB - Seizures in the neonatal period are a frequent and ominous sign of a multitude of conditions. Quick and effective treatment is important to prevent late sequelae in cognitive development; treatment efficacy however depends on the underlying cause. It is also hampered by the sometimes-difficult recognition of seizures in the setting of a neonatal intensive care unit in often critically ill children, as neonatal seizures might be very subtle in their manifestation. Simultaneous video EEG studies are at times necessary to correctly identify all seizure events. They may present as focal clonic seizures, oral automatisms, grimacing, complex movements like pedaling, myoclonic seizures or tonic seizures, and rarely as apnea. The most important cause of neonatal seizures is birth asphyxia. Inborn errors of metabolism as a group are also important, and prompt recognition of the few treatable disorders is crucial for preserving the potential of normal development. In this chapter, we would like to present the inborn errors of metabolism presenting with neonatal seizures (see also Tables 15–1 and 15–2) and focus on treatable disorders, offering algorithms for treatment and the diagnostic approach. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1138410145 ER -