TY - CHAP M1 - Book, Section TI - Endocrine-Related Cancer A1 - Stratakis, Constantine A. A1 - Pacak, Karel A1 - Bauer, Andrew J. A2 - Sarafoglou, Kyriakie A2 - Hoffmann, Georg F. A2 - Roth, Karl S. PY - 2017 T2 - Pediatric Endocrinology and Inborn Errors of Metabolism, 2e AB - Thyroid carcinoma is the most common endocrine tumor in children (and in adults); approximately 10% of thyroid cancers are diagnosed before 19 years of age. Similar to adults, the most common presentation is an asymptomatic nodule noted on physical examination; however, thyroid nodules are reported much less frequently in children, and the risk of malignant disease appears to be much higher, with 20% to 25% of pediatric nodules found to have carcinoma compared with 10% to 14% of adults.1 In addition, at diagnosis, approximately 60% of children have regional lymph node metastasis, and up to 15% to 20% with lateral lymph node metastasis will have pulmonary metastasis.2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1140324479 ER -