TY - CHAP M1 - Book, Section TI - Pathophysiology of Sepsis A1 - Nguyen, Trung C. A1 - Carcillo, Joseph A. A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Sepsis continues to be the leading cause of death among children worldwide, accounting for more than 5.9 million deaths per year according to data from the World Health Organization and the United Nations Children’s Fund. In the United States, sepsis poses a significant healthcare burden with approximately 75,000 children admitted annually to hospitals with severe sepsis and an associated cost of $4.8 billion. Understanding the pathophysiology of systemic inflammatory response syndrome (SIRS) and sepsis syndrome is essential for recognition and management of this deadly disease. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/16 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182925201 ER -