TY  - CHAP
M1  - Book, Section
TI  - Antibacterial Therapy
A1  - Schleiss, Mark R.
A2  - Kline, Mark W.
PY  - 2018
T2  - Rudolph's Pediatrics, 23e
AB  - Antibacterial  therapy  in  infants  and  children  presents  many  unique  challenges  not  faced  in  other  clinical  specialties.  A  major  problem  is  the  paucity  of  pediatric  data  regarding  efficacy,  pharmacokinetics,  and  optimal  dosages;  pediatric  recommendations  are  therefore  often  extrapolated  from  studies  in  adults.  Age-appropriate  antibiotic  dosing  and  toxicities  must  also  be  considered,  taking  into  account  the  developmental  status  and  physiology  of  children.  The  clinician  must  consider  important  differences  among  various  age  groups  with  respect  to  the  pathogenic  bacterial  species  responsible  for  pediatric  infections.  Specific  antibiotic  therapy  is  optimally  driven  by  a  microbiologic  diagnosis,  predicated  on  isolation  of  the  pathogenic  organism  from  a  normally  sterile  body  site,  and  supported  by  antimicrobial  susceptibility  testing.  Given  the  inherent  difficulties  that  can  arise  in  collecting  specimens  from  pediatric  patients  and  given  the  increased  risk  of  serious  bacterial  infection  in  young  infants,  much  of  pediatric  infectious  diseases  practice  is  based  on  clinical  diagnosis  with  empirical  use  of  antibacterial  agents  before  or  even  without  eventual  identification  of  the  specific  pathogen.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1182935171
ER  -