TY - CHAP M1 - Book, Section TI - Delayed Puberty, Girls A1 - Hay, Jr, William W. A1 - Levin, Myron J. A1 - Deterding, Robin R. A1 - Abzug, Mark J. PY - 2017 T2 - Quick Medical Diagnosis & Treatment Pediatrics AB - Indications for evaluationNo pubertal signs by age 13 yearsNo menarche by age 16 yearsMost common cause of delayed puberty is constitutional growth delayPrimary hypogonadism in girls refers to a primary abnormality of the ovariesMost common diagnosis in this category is Turner syndromeOther types of primary ovarian insufficiency include46,XY and 46,XX gonadal dysgenesisGalactosemiaAutoimmune ovarian failureRadiation, chemotherapyPremutation carriers for fragile X syndrome are also at increased risk for premature ovarian failureCentral hypogonadismRefers to a hypothalamic or pituitary deficiency of gonadotrophin-releasing hormone (GnRH) or follicle-stimulating hormone/luteinizing hormone (FSH/LH), respectivelyCan be functional (reversible), caused by stress, undernutrition, prolactinemia, excessive exercise, or chronic illnessCan be permanent, which is typically associated with conditions that cause multiple pituitary hormone deficiencies, such as congenital hypopituitarism, CNS tumors, or cranial irradiationIsolated gonadotropin deficiency is rare but may occur in Kallmann syndrome SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1145455008 ER -