TY - CHAP M1 - Book, Section TI - Pulmonary Hypertension, Persistent A1 - Hay, Jr, William W. A1 - Levin, Myron J. A1 - Deterding, Robin R. A1 - Abzug, Mark J. PY - 2017 T2 - Quick Medical Diagnosis & Treatment Pediatrics AB - Onset of symptoms on day 1 of lifeHypoxia with poor response to high concentrations of inspired oxygenRight-to-left shunts through the foramen ovale, ductus arteriosus, or bothMost often associated with parenchymal lung diseaseThere are three underlying pathophysiologic mechanismsVasoconstriction due to perinatal hypoxia related to an acute event such as sepsis or asphyxiaPrenatal increase in pulmonary vascular smooth muscle development, often associated with meconium aspiration syndromeDecreased cross-sectional area of the pulmonary vascular bed associated with lung hypoplasia (eg, diaphragmatic hernia) SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1145458187 ER -