TY - CHAP M1 - Book, Section TI - Osteosarcoma A1 - Janeway, Katherine A. A1 - Gorlick, Richard A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Osteosarcoma should be considered in the differential diagnosis of bone pain, as early recognition may increase the likelihood that radiographically visible metastatic disease, which adversely impacts patient prognosis, will not develop between the time of symptom onset and diagnosis. In addition to its importance as a clinical entity, its rigorous study, beginning with an osteosarcoma registry created under the auspices of the American College of Surgeons in 1921, highlights important oncologic principles, including the concept of microscopic metastatic disease and the role of adjuvant therapy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/08 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182911310 ER -