TY - CHAP M1 - Book, Section TI - Kawasaki Disease A1 - Son, Mary Beth F. A1 - Newburger, Jane W. A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Kawasaki disease, an acute febrile illness of childhood, was described in Japan in 1967 by Dr. Tomasaku Kawasaki as the mucocutaneous lymph node syndrome. A vasculitis of medium-sized vessels, Kawasaki disease has a predilection for the coronary arteries, and 20% to 25% of untreated children develop coronary artery aneurysms. Fortunately, a regimen of intravenous immunoglobulin and aspirin reduces the incidence of coronary artery abnormalities to less than 5%. Nonetheless, Kawasaki disease is the leading cause of acquired heart disease in children in North America and Japan. Furthermore, the etiology of Kawasaki disease remains elusive, impeding the development of targeted therapy and diagnostic testing. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182914363 ER -