TY  - CHAP
M1  - Book, Section
TI  - Skin Disease in Immunosuppressed Hosts
A1  - Berger, Emily M.
A1  - Perman, Marissa J.
A2  - Zaoutis, Lisa B.
A2  - Chiang, Vincent W.
PY  - 2017
T2  - Comprehensive Pediatric Hospital Medicine, 2e
AB  - A  wide  variety  of  cutaneous  disorders  may  affect  immunocompromised  pediatric  patients.  Children  can  be  immunocompromised  due  to  an  underlying  malignancy,  immunodeficiency,  or  secondary  to  immunosuppressive  therapy.  Chronic  immunosuppressive  therapies  may  be  administered  for  numerous  reasons  including  solid  organ  transplantation  and  chronic  conditions.  In  addition,  immunosuppression  may  result  from  chemotherapeutic  treatment  regimens  for  malignancies  or  conditioning  regimens  in  preparation  for  bone  marrow  or  stem  cell  transplantation.  The  cutaneous  disorders  associated  with  immunosuppression  range  in  severity.  Even  the  most  banal  skin  lesions  in  immunocompromised  children  can  herald  life-threatening  conditions.  Skin  biopsies  can  thus  be  useful  tools  in  immunosuppressed  patients  with  skin  lesions  to  aid  in  diagnosis.1  Skin  lesions  are  most  frequently  a  consequence  of  drug  side  effects  or  infection  caused  by  immunosuppression.2,3  Skin  disorders  affecting  immunocompromised  patients  may  occur  acutely  during  high  levels  of  immunosuppression  (such  as  in  transplant  patients  during  the  early  post-transplant  period  or  during  periods  of  acute  rejection),  while  other  skin  eruptions  may  be  secondary  to  exposure  to  various  medications.  Table  66-1  displays  a  range  of  cutaneous  lesions  seen  in  immunocompromised  patients.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1146115986
ER  -