TY  - CHAP
M1  - Book, Section
TI  - Disorders of Pituitary Function
A1  - Shah, Rachana
A2  - Zaoutis, Lisa B.
A2  - Chiang, Vincent W.
PY  - 2017
T2  - Comprehensive Pediatric Hospital Medicine, 2e
AB  - The  pituitary  gland  is  comprised  of  two  parts  with  distinct  origins.  The  anterior  pituitary  is  derived  embryonically  from  Rathke’s  pouch  of  oral  ectoderm,  while  the  posterior  pituitary  is  of  neuroectoderm  origin.  The  pituitary  gland  regulates  endocrine  target  organs,  such  as  the  adrenal  gland,  ovary,  testis,  and  thyroid  gland.  Disorders  of  the  pituitary  and  hypothalamus  may  therefore  result  in  disruption  of  any  of  these  hypothalamic-pituitary–target  organ  axes.  Abnormalities  in  end-organ  hormone  release  caused  by  pituitary  dysfunction  are  considered  “secondary,”  and  those  caused  by  a  hypothalamic  abnormality  are  considered  “tertiary.”  For  example,  abnormal  thyroid  function  caused  by  a  decrease  in  pituitary  thyroid  stimulated  hormone  is  considered  “secondary  hypothyroidism”  while  hypothyroidism  due  to  deficient  thyrotropin-releasing  factor  from  the  hypothalamus  is  “tertiary  hypothyroidism.”  Failure  of  growth  and  failure  of  sexual  maturation  are  two  common  presentations  of  hypothalamic-pituitary  disease  in  the  pediatric  population.  Pituitary  disorders  may  be  genetic  or  acquired.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1146116318
ER  -