TY - CHAP M1 - Book, Section TI - Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome A1 - Hazen, Melissa M. A2 - Zaoutis, Lisa B. A2 - Chiang, Vincent W. PY - 2017 T2 - Comprehensive Pediatric Hospital Medicine, 2e AB - Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are clinically related life-threatening immune dysregulatory processes characterized by fever, systemic inflammation, organomegaly, coagulopathy, and hematologic cytopenias. Both conditions may also include neurologic symptoms, often accompanied by cerebrospinal fluid and brain imaging abnormalities. HLH and MAS are defined histologically by the phagocytosis of hematopoietic cells by normal-appearing macrophages. This hemophagocytosis is most typically seen on samples from bone marrow aspirates, but it can also be seen in the spleen and in other lymphatic tissue. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1146122514 ER -