TY - CHAP M1 - Book, Section TI - Infant Botulism A1 - Vecchio, Michael Del A2 - Zaoutis, Lisa B. A2 - Chiang, Vincent W. PY - 2017 T2 - Comprehensive Pediatric Hospital Medicine, 2e AB - Infant botulism, the most common form of botulism encountered in the United States, has a unique pathogenesis. Unlike food-borne botulism, which results from the ingestion of preformed toxin, infant botulism occurs following the ingestion of Clostridium botulinum spores that germinate and colonize the infant gut. Botulinum neurotoxin is produced in vivo and absorbed, producing clinical disease. This form of botulism occurs almost exclusively in children younger than 1 year1. The first clear association of in vivo production of botulinum neurotoxin and a syndrome of weakness in infants was described in 1976.2 Subsequently, the pathophysiology, epidemiology, clinical manifestations, and specific therapy have been elucidated. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1146124321 ER -