TY - CHAP M1 - Book, Section TI - Anticoagulants and Antithrombotics A1 - Levine, Michael A2 - Zaoutis, Lisa B. A2 - Chiang, Vincent W. PY - 2017 T2 - Comprehensive Pediatric Hospital Medicine, 2e AB - Under normal homeostatic conditions, the human body is at a constant balance between clot formation and destruction. Physiologic hemostasis occurs as a result of a complex interaction among platelets, the vascular endothelium, the coagulation cascade, and the fibrinolytic system. Any disorder or xenobiotic that alters this equilibrium can produce either excessive thrombosis or hemorrhage. Numerous pharmacologic agents have been developed to prevent thrombus formation by interfering with platelet adhesion or aggregation, or by interfering with the clotting cascade. Numerous additional drugs, including those working by novel mechanisms, are in various stages of development.1 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/07 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1146124493 ER -