TY - CHAP M1 - Book, Section TI - Disorders of Purine and Pyrimidine Metabolism A1 - El-Hattab, Ayman W. A1 - Scaglia, Fernando A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Purines (adenine and guanine) and pyrimidines (thymine, cytosine, and uracil) are nitrogenous bases that are essential components of nucleotides. The addition of pentose monosaccharide (ribose or deoxyribose) to a base results in a nucleoside, which can be a ribonucleoside (adenosine, guanosine, cytidine, and uridine) or a deoxyribonucleoside (deoxyadenosine, deoxyguanosine, deoxycytidine, and thymidine). Nucleotides result from the binding of nucleosides to phosphate. The binding of a nucleoside to 1, 2, or 3 phosphate groups produces nucleoside mono-, di-, or triphosphate, respectively. Nucleotides are essential for all cells. In addition to their vital role as building blocks for DNA and RNA, they serve as carriers of activated intermediates in the synthesis of a variety of complex molecules, structural components of several essential coenzymes, messengers in signal transduction pathways, regulatory components for many of the metabolic pathways, and currency for energy transfer in cells. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/08 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182930379 ER -