TY - CHAP M1 - Book, Section TI - Varicella-Zoster Virus Infections A1 - Poole, Claudette L. A1 - Kimberlin, David W. A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Varicella-zoster virus (VZV) is 1 of the 9 human herpesviruses, which include herpes simplex virus (HSV) types 1 and 2, cytomegalovirus, Epstein-Barr virus, and human herpesviruses 6A, 6B, 7, and 8. As with HSV-1 and HSV-2, VZV establishes latency in sensory or autonomic ganglia following primary infection, with the ability for subsequent reactivation. The primary acquisition of VZV results in the clinical disease varicella (chickenpox) with reactivation from latency resulting in zoster (shingles). Live-attenuated varicella vaccine was licensed in the United States in 1995 and, over the past 20 years, has substantially altered the epidemiology of the disease in this country, with rates of varicella and its complications plummeting. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/11 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182903470 ER -