TY - CHAP M1 - Book, Section TI - Hemoglobinopathies A1 - George, Alex A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Normal hemoglobin (Hb) structure and developmental changes in production are detailed in Chapter 425. Thousands of variants in the α-, β-, minor, and fetal globin genes have been described, some of which are associated with tremendous morbidity or mortality. However, most hemoglobin variants have no clinically significant effect on hemoglobin or red blood cell (RBC) function. A continuously updated listing of Hb variants, many of which are named after the town or geographic regions where they were identified (eg, Hb Köln), is provided in the HbVar database at http://globin.cse.psu.edu/hbvar/menu.html. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/12 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182909969 ER -