TY - CHAP M1 - Book, Section TI - The Adrenal Cortex A1 - Miller, Walter L. A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Human embryonic mesodermal adrenogonadal progenitor cells, which give rise to the steroidogenic cells of the gonads and the adrenal cortex, first appear around the fourth week of gestation between the urogenital ridge and dorsal mesentery. The adrenal and gonadal cells then separate; the adrenal cells migrate retroperitoneally to the cranial pole of the mesonephros, and the gonadal cells migrate caudally. Between the seventh and eighth weeks of development, sympathetic neuroectodermal cells from the neural crest invade the primitive adrenal and become the adrenal medulla. By the end of the eighth week, the rudimentary adrenal has become encapsulated and is associated with the upper pole of the kidney, which at this time is much smaller than the adrenal. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/20 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182919551 ER -