TY - CHAP M1 - Book, Section TI - Diabetic Ketoacidosis A1 - Rozenfeld, Ranna A. PY - 2018 T2 - The PICU Handbook AB - Diabetic ketoacidosis (DKA) mainly affects children with type 1 diabetes mellitus (T1DM) and is caused by a deficiency in circulating insulin levels and elevations in other hormones like glucagon and cortisol. This, in turn, leads to:Impaired glucose consumption by the peripheral tissues with elevations in plasma glucose levelsIncreased glucose production by the liver through gluconeogenesis and glycogenolysisIncreased serum osmolalityIncreased lipolysis with production of ketone bodies (ß-hydroxybutyrate) and resultant ketonemiaProfound anion gap metabolic acidosis SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/15 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1152488797 ER -