TY - CHAP M1 - Book, Section TI - Acute Liver Failure A1 - Rozenfeld, Ranna A. PY - 2018 T2 - The PICU Handbook AB - Symptoms may include nausea, vomiting, itching, fever.Signs may include encephalopathy, ascites, scleral icterus/jaundice.Though there are no strict diagnostic criteria, consider acute liver failure if all of these are present:Hepatic failure within 8 weeks of onset of hepatic diseaseElevated serum AST, ALT, and/or bilirubinCoagulopathy (PT >15, INR >1.5) does not correct with vitamin KNo prior history of chronic liver diseaseEncephalopathy (confirmatory, not required) SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1152489063 ER -