TY - CHAP M1 - Book, Section TI - Anaphylaxis A1 - Rozenfeld, Ranna A. PY - 2018 T2 - The PICU Handbook AB - Etiology: An acute multisystem response caused by a severe reaction to any antigen, such as a drug, vaccine, food, toxin, plant, or venomClinical Presentation:Systemic vasodilation:HypotensionTachycardiaIncreased capillary permeability:Angioedema – may lead to partial or complete airway obstructionWorsens hypotensionPulmonary vasoconstriction:Decreased pulmonary blood flowIncreased right ventricular afterloadDecreased left ventricular preloadBronchoconstriction/bronchospasmRespiratory distress +/− stridor, wheezing, or bothHistamine release:UrticariaNausea and vomiting SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/02 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1152489233 ER -