TY - CHAP M1 - Book, Section TI - De Sanctis-Cacchione Syndrome A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - De Sanctis-Cacchione Syndrome belongs to a group of rare inherited skin disorders called xeroderma pigmentosum that are characterized by photosensitivity, skin discolorations, eye disorders, and skin cancers. Clinical features of this medical condition include neurological abnormalities, mental retardation, dwarfism, and hypogonadism. Mental retardation, microcephaly, ataxia, areflexia, hyporeflexia represent the most common neurological abnormalities observed in individuals affected with De Sanctis-Cacchione Syndrome. The onset of the disease is noticed during the first year of life; however, it has also been observed during early or late childhood. In regards to the onset of neurological abnormalities, it occurs as late as 5 to 10 years of age or even during the second decade of life. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164067574 ER -