TY - CHAP M1 - Book, Section TI - Glutaric Acidemia Type I (GA-I) A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - Progressive inherited neurologic disorder caused by a genetically transmitted inborn error of metabolism leading to break down completely the amino acids lysine, hydroxylysine and tryptophan. Excessive levels of their intermediate breakdown products, ie, glutaric acid, glutaryl-CoA, 3-hydroxyglutaric acid, and glutaconic acid can accumulate and cause damage to the brain. The basal ganglias are most often affected which may cause neurological irregular movement. Mental retardation may occur. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/10 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164070933 ER -