TY - CHAP M1 - Book, Section TI - Homocystinuria (HCU) A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - Genetically transmitted error of metabolism of the amino acid methionine leading to a multisystemic disorder of the connective tissue, muscles, central nervous system, and cardiovascular system. It is characterized by severe myopia, Marfan-like stature with pectus excavatum, slight mental retardation, and tendency to develop spontaneous, generalized arterial, and venous thromboses under stress. A special consideration must be given to anesthesiologists using nitrous oxide during anesthesia. An association between its administration and the potential risk for an acute and severe thromboembolism syndrome must be taken into consideration. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164073107 ER -