TY - CHAP M1 - Book, Section TI - MELAS Syndrome A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - MELAS is an acronym that stands for Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke. It is a progressive neurodegenerative disorder that is part of a family of mitochondrial cytopathies that includes MERRF and Leber’s Hereditary Optic Neuropathy (see Other conditions to be considered below). It is characterized by early symptoms of generalized seizures, recurrent headaches, loss of appetite, and recurrent vomiting. Stroke-like episodes with temporary hemiparesis muscle weakness may also occur, affecting consciousness, vision, hearing, motor skills, and intellectual functions. Other clinical features include diabetes mellitus, deafness, episodic vomiting, seizures, and cortical blindness. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164078242 ER -