TY - CHAP M1 - Book, Section TI - Miller-Dieker Lissencephaly Syndrome A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - Malformation of the cerebral cortex with abnormal facies. Classic lissencephaly, also known as lissencephaly type I, is a brain malformation that may occur as an isolated abnormality (isolated lissencephaly sequence) or in association with certain underlying syndromes (eg, Miller-Dieker Syndrome, Norman-Roberts Syndrome). The condition is characterized by agyria or pachygyria of the gyri of the cerebral cortex, causing the brain’s surface to appear unusually smooth. In infants with classic lissencephaly, microcephaly is usually present. Other clinical features include seizures, severe or profound mental retardation, feeding difficulties, growth retardation, and impaired motor functions. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164078741 ER -