TY - CHAP M1 - Book, Section TI - Opitz-Frias Syndrome A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - Genetic disorder characterized by craniofacial anomalies, ocular hypertelorism, cleft lip and palate, epicanthal folds, and a wide, flat nasal bridge. Affected males present cryptorchidism, bifid scrotum, and/or hypospadias. The most significant anomalies are the presence of cleft in the larynx and trachea, pulmonary hypoplasia, dysphagia, and respiratory obstruction. Hypoplasia or agenesis of the corpus callosum, kidney abnormalities, cardiac defects, and mental retardation have been reported. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164080626 ER -