TY  - CHAP
M1  - Book, Section
TI  - Osteopenia of Prematurity (Metabolic Bone Disease)
A1  - Gomella, Tricia Lacy
A1  - Eyal, Fabien G.
A1  - Bany-Mohammed, Fayez
PY  - 2020
T2  - Gomella's Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 8e
AB  - Prematurity  affects  bone  mineralization  and  bone  mineral  content  (BMC).  Metabolic  bone  disease  (MBD)  of  prematurity  is  a  term  currently  used  more  often  compared  with  osteopenia  of  prematurity.  MBD  is  best  defined  as  a  decrease  in  BMC  relative  to  expected  level  of  mineralization  for  gestational  age  (GA)  with  biochemical  and  radiologic  features.  Normal  bone  is  formed  by  the  deposition  of  minerals,  predominantly  calcium  (Ca2+)  and  phosphorus  (P),  onto  an  organic  matrix  (osteoid)  secreted  by  the  osteoblasts.  Osteoclasts  play  an  important  role  in  bone  resorption  and  remodeling.  Although  osteopenia  and  rickets  result  in  decreased  bone  mineralization  and  may  have  similar  clinical  findings,  they  are  not  identical  processes  and  thus  the  term  rickets  of  prematurity  is  not  used  in  this  chapter.  Osteopenia  or  MBD  is  principally  a  result  of  inadequate  Ca2+  and  P  intake  to  meet  bone  growth  demands.  Rickets,  however,  is  principally  due  to  vitamin  D  deficiency;  vitamin  D  supplementation  alone  will  not  resolve  either  osteopenia  or  rickets.  Both  disease  processes  involve  the  utilization  of  Ca2+,  P,  and  vitamin  D.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2021/05/11
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1168358123
ER  -