TY - CHAP M1 - Book, Section TI - Chapter 63. Mononucleosis Syndromes A1 - Marshall, Beth C. A1 - Koch, William C. A2 - Shah, Samir S. PY - 2009 T2 - Pediatric Practice: Infectious Disease AB - Infectious mononucleosis is a clinical syndrome classically defined by the presence of fever, lymphadenopathy, pharyngitis, and fatigue. The illness was first recognized in the late 19th century and termed “glandular fever” or “Drusenfieber” by German physicians who noted its frequent occurrence in the context of family outbreaks.1,2 In a 1920 Johns Hopkins Medical Bulletin, Sprunt and Evans described 6 previously healthy young adults with a febrile illness similar to glandular fever, and noted the presence of atypical lymphocytes in the peripheral blood smear; because of the predominance of these unusual mononuclear cells, they termed the syndrome “infectious mononucleosis.”3 Twelve years later while investigating rheumatic disease, Paul and Bunnell4 serendipitously noted that the serum of patients with symptoms of infectious mononucleosis contained high titers of antibodies that agglutinated sheep red blood cells, thus the detection of these “heterophile antibodies” became the first laboratory marker available to diagnose the illness. The association of Epstein-Barr virus (EBV) with infectious mononucleosis followed in the late 1960s when a laboratory technician working with specimens from patients with Burkitt's lymphoma, a condition which had recently been shown to be associated with EBV, accidentally became infected and developed clinical infectious mononucleosis.5,6 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/10/07 UR - accesspediatrics.mhmedical.com/content.aspx?aid=6913772 ER -