TY - CHAP M1 - Book, Section TI - Chapter 352. Malaria A1 - John, Chandy C. A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. PY - 2011 T2 - Rudolph's Pediatrics, 22e AB - Malaria is among the leading infectious causes of morbidity and mortality in children worldwide. Each year, there are 300 to 500 million clinical cases, causing between 1.5 and 2.7 million deaths, most in sub-Saharan African children under the age of 5 years. Increasing drug resistance, climatic changes, population shifts, economic changes, abandonment of malaria control programs, and insecticide resistance all contributed to a resurgence of malaria in the developing world from the 1970s to the 2000s. Recent World Health Organization, governmental, and nonprofit foundation support for effective preventative measures—such as insecticide-treated bednets, indoor residual spraying, and the implementation of artemisinin combination therapy as first-line treatment for malaria in many sub-Saharan African countries—appears to have significantly reduced malaria incidence and deaths in some countries.1 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=7031920 ER -