TY  - CHAP
M1  - Book, Section
TI  - Chapter 356. Functional Overview
A1  - Tlougan, Brook E.
A1  - Paller, Amy S.
A2  - Rudolph, Colin D.
A2  - Rudolph, Abraham M.
A2  - Lister, George E.
A2  - First, Lewis R.
A2  - Gershon, Anne A.
PY  - 2011
T2  - Rudolph's Pediatrics, 22e
AB  - The  skin,  the  largest  organ  in  the  body,  plays  many  roles  as  the  major  interface  with  the  external  environment.1-3  The  outermost  skin  layer,  the  stratum  corneum,  prevents  desiccation  of  a  primarily  aqueous  body  in  a  dry  atmosphere.  Extensive  burns,  drug-induced  skin  necrosis  (toxic  epidermal  necrolysis),  and  other  extensive  blistering  disorders,  such  as  epidermolysis  bullosa,  represent  situations  in  which  the  barrier  is  breached,  leading  to  increased  morbidity  and  mortality.  In  addition  to  providing  a  physical  barrier  to  infection,  the  skin  is  an  important  component  of  the  body’s  immune  system.  Langerhans  cells  provide  immune  surveillance,  presenting  antigen  that  activates  lymphocytes.  When  the  immune  function  in  skin  is  dysfunctional,  as  in  atopic  dermatitis,  the  risk  of  infection  is  increased.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/24
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=7032486
ER  -