TY  - CHAP
M1  - Book, Section
TI  - Chapter 463. Histiocytic Disorders
A1  - Egeler, Maarten
A1  - Arceci, Robert J.
A1  - Henter, Jan-Inge
A2  - Rudolph, Colin D.
A2  - Rudolph, Abraham M.
A2  - Lister, George E.
A2  - First, Lewis R.
A2  - Gershon, Anne A.
PY  - 2011
T2  - Rudolph's Pediatrics, 22e
AB  - Under  the  term  histiocytoses,  we  consider  a  group  of  disorders  that  have  in  common  the  proliferation  of  cells  of  the  mononuclear  phagocytic  system  and  the  dendritic  cell  (DC)  system.  Normally,  histiocytes  (tissue  macrophages)  and  DCs  are  involved  in  immune  and  inflammatory  responses.  The  histiocytoses  are  each  characterized  by  localized  or  generalized  reactive  or  neoplastic  proliferation  of  cells  similar,  if  not  identical,  to  one  of  these  cell  types.  They  are  diagnosed  on  the  basis  of  characteristic  signs,  symptoms,  and  laboratory  findings  that,  in  combination  with  specific  histological  features,  satisfy  diagnostic  criteria.  In  the  case  of  Langerhans  cell  histiocytosis  (LCH),  the  proliferating  cell  is  the  Langerhans  cell,  and  in  hemophagocytic  lymphohistiocytosis  (HLH),  the  macrophage  accumulates.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=7044074
ER  -