TY - CHAP M1 - Book, Section TI - Chapter 465. Development of Renal Function A1 - Piscione, Tino D. A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. PY - 2011 T2 - Rudolph's Pediatrics, 22e AB - In the perinatal period, kidney function, as it relates to fluid and electrolyte homeostasis in the premature and full-term neonate, is predominantly influenced by (1) anatomical kidney development at the time of birth, (2) physiologic adaptations that occur during the transition from intrauterine to extrauterine environment, and (3) diminished capacity of the newborn kidney to respond to increased fluid, electrolyte, or acid load. Their combined effects on renal function in the newborn infant are in indirect proportion to gestational age such that premature infants are most vulnerable to effects of anatomical immaturity, changes in renal blood flow, and limited functionality of hormonal regulatory mechanisms. Consequently, a clear understanding of changes in glomerular and tubular function and renal hemodynamics in the perinatal period is crucial for appropriate management of fluid and electrolyte problems in the sick neonate. In this chapter, general and specific aspects of renal function as they relate to the antenatal and postnatal periods are reviewed to provide a framework for evaluating renal function in the healthy and sick newborn infant. Diagnostic and therapeutic aspects regarding normal and abnormal renal function are discussed elsewhere. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=7044350 ER -