TY - CHAP M1 - Book, Section TI - Chapter 474. Renal Tubular Disorders A1 - Baum, Michel A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. PY - 2011 T2 - Rudolph's Pediatrics, 22e AB - The glomeruli filter approximately 150 liters of ultrafiltrate daily that are delivered to the renal tubules. The renal tubules reabsorb organic solutes, salt, and water to maintain a constant extracellular fluid volume and composition. In addition, organic anions and cations, which are protein bound and not filtered by the glomerulus, are secreted by the proximal tubule. The final urine contains about one hundredth of the volume and sodium as that in the original glomerular filtrate, but contains all waste products. There are 12 nephron segments that have different transport properties to perform this task. Disorders of tubular function can be due to inherited defects in transporters or mutations in factors that regulate transport, or result from inherited or acquired disorders that cause tubular injury. Renal transport disorders can be mild with little to no clinical consequences, or life threatening, depending on the transporters and nephron segments affected. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=7045821 ER -