TY - CHAP M1 - Book, Section TI - Chapter 525. Primary Disturbances in Water Homeostasis A1 - Srivatsa, Abhinash A1 - Majzoub, Joseph A. A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. PY - 2011 T2 - Rudolph's Pediatrics, 22e AB - Maintenance of the tonicity of extracellular fluids within a very narrow range is crucial for proper cell function. Normal blood tonicity is maintained over a 10-fold variation in water intake by a coordinated interaction among the vasopressin, thirst, and renal systems. Dysfunction in any of these systems can result in abnormal regulation of blood osmolality, which if not properly recognized and treated, may cause life-threatening hyperosmolality or hypoosmolality.1 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=7053090 ER -