TY  - CHAP
M1  - Book, Section
TI  - Chapter 1. Genetics of Neonatal Jaundice
A1  - Watchko, Jon F.
A1  - Lin, Zhili
A2  - Stevenson, David K.
A2  - Maisels, M. Jeffrey
A2  - Watchko, Jon F.
PY  - 2012
T2  - Care of the Jaundiced Neonate
AB  - Neonatal  hyperbilirubinemia  and  resultant  jaundice  are  common,1,2  affecting  up  to  ˜80%  of  newborns.1  Although  generally  a  benign  postnatal  transitional  phenomenon,  a  select  number  of  infants  develop  more  significant  and  potentially  hazardous  levels  of  total  serum  bilirubin  (TSB)  (Table  1-1)3,4  that  may  pose  a  direct  threat  of  brain  damage.3,5,6  Numerous  factors  contribute  to  the  development  of  hyperbilirubinemia  including  genes  involved  in:  (i)  the  production  of  bilirubin  from  heme;  (ii)  the  metabolism  of  bilirubin;  and  (iii)  heritable  conditions  that  may  reduce  red  blood  cell  (RBC)  life  span  and  predispose  to  hemolysis,  thereby  increasing  the  bilirubin  load7–17  in  neonates.  The  genetics  of  neonatal  hyperbilirubinemia  is  the  focus  of  this  chapter.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=56321101
ER  -