TY - CHAP M1 - Book, Section TI - Langerhans Cell Histiocytosis A1 - Thomas, Stefanie A1 - Thompson, Margaret C. A2 - Usatine, Richard P. A2 - Sabella, Camille A2 - Smith, Mindy Ann A2 - Mayeaux, E.J. A2 - Chumley, Heidi S. A2 - Appachi, Elumalai PY - 2015 T2 - The Color Atlas of Pediatrics AB - A 3-month-old female infant presented to her pediatrician with a history of a rash that had been present from birth. Her parents report that her rash initially involved her face and trunk, and the lesions had a red base. The rash seemed to slightly improve over the first 2 weeks of her life, but then progressed into red and brown, rough lesions involving her head, face, trunk, and spread to her back then bilateral lower extremities (Figures 214-1 and 214-2). They have also noted that her right eye has been watering and she has not been able to open it completely over the past few days. Based on the appearance and persistence of the rash, she was referred to a dermatologist, who performed a skin biopsy, which showed CD1 positive immuno-histochemical staining, consistent with the diagnosis of Langerhans Cell Histiocytosis. Further work-up included a skull film, which revealed an ocular bony lesion (Figure 214-3). She underwent treatment with a chemotherapy regimen and has done well without evidence of recurrence. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1114880249 ER -