TY - CHAP M1 - Book, Section TI - Vesicoureteral Reflux A1 - Wells, Robert G. PY - 2015 T2 - Diagnostic Imaging of Infants and Children AB - Vesicoureteral reflux (VUR) is the intermittent reversal of normal antegrade flow of urine from the ureter into the bladder. In most affected patients, the important clinical consequence of VUR is the occurrence of recurrent infections that can lead to renal scarring. The major pathophysiological mechanism of scarring is thought to be passage of infected urine from the lower urinary tract into the pelvicaliceal system, with extension into the parenchyma by way of intrarenal reflux through the collecting tubules. When severe, renal scarring can lead to hypertension or renal failure. Severe VUR in the fetus or neonate can lead to renal damage or faulty kidney development. Primary VUR accounts for 15% to 20% of prenatally detected uropathies; this type of reflux occurs with a 5:1 male to female ratio.1 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/06 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1148951284 ER -