TY  - CHAP
M1  - Book, Section
TI  - Hematological and Ischemic Bone Disease
A1  - Wells, Robert G.
PY  - 2015
T2  - Diagnostic Imaging of Infants and Children
AB  - The  pathophysiological  consequence  of  bone  ischemia  is  avascular  necrosis  (osteonecrosis)  or  bone  infarction.  Interruption  of  the  blood  supply  to  the  bone  can  result  from  acute  thrombosis,  trauma,  an  underlying  vascular  disease,  or  a  predisposing  osseous  disorder.  A  process  that  leads  to  elevation  of  the  intramedullary  pressure  (e.g.,  pyogenic  infection)  can  impede  perfusion  to  the  point  that  ischemic  necrosis  occurs.  In  addition  to  infection,  conditions  that  are  commonly  associated  with  ischemic  bone  disease  in  children  include  sickle  cell  disease,  steroid  therapy,  trauma,  hemophilia,  irradiation,  collagen  vascular  disease,  Gaucher  disease,  and  Cushing  syndrome.  Various  sites  in  the  pediatric  skeleton  can  also  be  involved  with  idiopathic  ischemic  necrosis;  the  most  common  of  these  is  the  hip,  that  is,  Legg-Calvé-Perthes  disease.  Ischemia  in  the  developing  epiphysis  of  a  child  can  result  in  growth  disturbance  due  to  chondrocyte  injury  or  death  in  the  germinal  zone  of  the  primary  physis  and  in  the  physis  of  the  secondary  ossification  center.  The  term  ischemic  necrosis  generally  refers  to  involvement  of  an  epiphysis  or  subarticular  area,  whereas  bone  infarct  indicates  the  consequence  of  ischemia  in  the  metaphysis  or  diaphysis.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1148953504
ER  -