TY - CHAP M1 - Book, Section TI - Congenital Diaphragmatic Hernia A1 - Frenckner, Björn A1 - Van Meurs, Krisa A2 - Stevenson, David K. A2 - Cohen, Ronald S. A2 - Sunshine, Philip PY - 2015 T2 - Neonatology: Clinical Practice and Procedures AB - Congenital diaphragmatic hernia (CDH) is a developmental defect in the diaphragm associated with herniation of the abdominal viscera and ipsilateral pulmonary hypoplasia most pronounced on the ipsilateral side. In the current era, approximately 64% of cases in the United States will be diagnosed prenatally by midtrimester ultrasound, and the majority of the remaining newborns will present in the first few hours of life with varying degrees of respiratory distress. Herniation occurring later in gestation is associated with less-significant pulmonary hypoplasia and milder respiratory distress in the newborn period and is often not prenatally diagnosed. Prenatal diagnosis and advances in neonatal care have improved survival to 75% for isolated CDH. However, newborns with more severe CDH and those with other congenital anomalies or chromosomal defects continue to have a significant risk of death and morbidities, such as chronic lung disease, pulmonary hypertension, gastroesophageal reflux, failure to thrive, hernia recurrence, chest wall deformities, scoliosis, and adverse neuro­developmental outcome. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1109793406 ER -