TY - CHAP M1 - Book, Section TI - Thrombophilic Disorders A1 - Effinger, Karen E. A1 - Jeng, Michael R. A2 - Stevenson, David K. A2 - Cohen, Ronald S. A2 - Sunshine, Philip PY - 2015 T2 - Neonatology: Clinical Practice and Procedures AB - Thromboembolic events are rare in childhood; however, neonates are disproportionately affected by thrombosis. The propensity for neonates to clot may be due to several contributing factors. First, neonates have an immature hemostatic system, which generally gives them physiologic thrombophilia. In addition, they are at high risk for sepsis, which leads to thrombosis due to inflammation or disseminated intravascular coagulopathy (DIC). The high use of central catheters, both arterial and venous, in neonates also increases their risk of thrombosis. Although often considered in neonatal thrombosis, the contributing role of inherited thrombophilias in both arterial and venous thrombotic events in this age group remains poorly defined. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/09 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1109794256 ER -