TY  - CHAP
M1  - Book, Section
TI  - Management of Perforated Necrotizing Enterocolitis
A1  - Dimmitt, Reed
A2  - Stevenson, David K.
A2  - Cohen, Ronald S.
A2  - Sunshine, Philip
PY  - 2015
T2  - Neonatology: Clinical Practice and Procedures
AB  - Necrotizing  enterocolitis  (NEC)  continues  to  be  associated  with  extreme  prematurity,  resulting  in  increased  morbidity  and  mortality.  Various  studies  have  reported  an  incidence  of  NEC  of  14%  in  infants  with  a  birth  weight  of  501–750  g  and  an  odds  ratio  for  death  of  14  for  nonsurgical  NEC  and  25  for  surgical  NEC.  There  remains  some  controversy  regarding  the  diagnosis  of  perforated  NEC  vs  spontaneous  intestinal  perforation,  and  an  ongoing  multicenter,  randomized,  controlled  trial  is  attempting  to  better  define  the  2  conditions.  Regardless  of  the  etiology,  severe  inflammation  and  subsequent  necrosis,  ischemia,  perforation,  and  peritonitis  may  result  in  not  only  death  but  also  severe  neurodevelopmental  impairment  and  intestinal  failure  (IF).  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1109798838
ER  -