TY - CHAP M1 - Book, Section TI - Initial Management of Metabolic Acidosis A1 - Cusmano-Ozog, Kristina A1 - Chapman, Kimberly A2 - Stevenson, David K. A2 - Cohen, Ronald S. A2 - Sunshine, Philip PY - 2015 T2 - Neonatology: Clinical Practice and Procedures AB - Metabolic acidosis in the neonate can have several causes, including increased acid intake from an exogenous source, increased endogenous production of an acid such as seen in an inborn error of metabolism (IEM), inadequate excretion of acid by the kidneys or excessive loss of bicarbonate in urine or stool. Presence or absence of an anion gap (AG) can help to distinguish the underlying etiology. The AG can be calculated using the following equation: AG = ([Na+]) − ([Cl−] + [HCO3−]). A normal AG is typically less than 16 mEq/L.1 Common anions that result in an elevated AG include lactate and the ketone bodies β-hydroxybutyrate and acetoacetate, as well as the accumulation of the toxic organic acids typically found in individuals with IEMs. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1109799269 ER -