TY - CHAP M1 - Book, Section TI - Acquired Epileptic Aphasia (Landau–Kleffner Syndrome) A1 - Hirsch, Edouard A2 - Duchowny, Michael A2 - Cross, J. Helen A2 - Arzimanoglou, Alexis Y1 - 2017 N1 - T2 - Pediatric Epilepsy AB - Acquired epileptic aphasia1 is an epileptic syndrome described in the International Classification of Epilepsies by the eponym Landau–Kleffner syndrome (LKS). Typical LKS2,3 is part of the epileptic encephalopathy of late childhood defined by1: age of onset ranging from 3 to 10 years in children with previously normal language development;2 insidious or abrupt acquired aphasia with verbal auditory agnosia; behavior disturbances (attention deficit and hyperactivity);3 seizures that may be nocturnal, focal motor, secondarily generalized, or atypical absences with an awake electroencephalographic (EEG) showing focal or multifocal spikes-and-waves predominantly over the temporal regions (Fig. 30–1);4 and sleep EEG reveals activation of interictal EEG abnormalities and, during the course of the syndrome in the acute phase, nonrapid eye movement (NREM) subcontinuous or continuous spike-waves during sleep (CSWS) (Fig. 30–1). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1138410966 ER -