TY  - CHAP
M1  - Book, Section
TI  - Tuberous Sclerosis Complex
A1  - Koh, Susan
A1  - Duchowny, Michael
A2  - Duchowny, Michael
A2  - Cross, J. Helen
A2  - Arzimanoglou, Alexis
Y1  - 2017
N1  - 
T2  - Pediatric Epilepsy
AB  - Tuberous  sclerosis  complex  (TSC)  is  an  inherited  neurocutaneous  disease  of  cell  differentiation  and  proliferation  affecting  multiple  organs  with  hamartomas  or  abnormal  neuronal  migration.  It  was  first  described  by  Bourneville  in  1880,  and  the  incidence  of  tuberous  sclerosis  in  the  population  is  reported  to  be  1/6000  to  1/10,000.1,2  Cortical  tubers  and  subependymal  nodules  (SEN)  are  the  hallmark  pathological  findings  in  children.  TSC  is  caused  by  aberrant  neuronal  migration  and  differentiation.  Radial  glial  fibers  guide  migration  of  neurons  during  development  from  the  3rd  to  5th  month  of  gestation,  and  if  there  is  a  disruption  in  one  tract,  hamartomas  may  develop.  This  process  of  abnormal  differentiation  also  explains  the  occurrence  of  hamartomas  outside  the  CNS.3  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1138411056
ER  -