TY  - CHAP
M1  - Book, Section
TI  - Urea Cycle Disorders
A1  - Yudkoff, Marc
A1  - Summar, Marshall L.
A1  - Häberle, Johannes
A2  - Sarafoglou, Kyriakie
A2  - Hoffmann, Georg F.
A2  - Roth, Karl S.
Y1  - 2017
N1  - 
T2  - Pediatric Endocrinology and Inborn Errors of Metabolism, 2e
AB  - Essentially  all  animal  cells  form  ammonia  in  the  course  of  the  metabolism  of  amino  acids  and  the  adenine  nucleotides.  Mammals  prevent  the  accumulation  of  ammonia,  which  is  neurotoxic  in  high  concentration,  by  converting  this  compound  to  urea  via  the  urea  cycle  (Figure  13-1),  which  was  “discovered”  in  1932  by  Krebs  and  Henseleit.1  Ureagenesis  is  an  extremely  efficient  mechanism  for  the  disposal  of  waste  nitrogen.  A  healthy  adult  who  daily  consumes  50  to  100  grams  of  protein  will  excrete  10  to  20  grams  of  nitrogen  (N)  as  urea,  or  80%  to  90%  of  total  urinary  N.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1140316009
ER  -